Madhouse Brewing Co. began in 2009 when Mason convinced a group of friends and family to contribute funds to finance the brewery. A used brewing system was purchased and set up in one of the former Maytag Corp. buildings in Newton, IA. Operations began with the production of two beers- Pastime Pale Ale and American Wheat.
During the first few years, new beers were tried and old beers were retired. Honey Pilsner replaced American Wheat. Hopburst IPA, Coffee Stout, and Imperial Red were added to the year-around lineup. Madhouse also began its barrel program with the release of the Templeton Rye Barrel-Aged Imperial Stout.
In 2013, Madhouse moved from the Newton location to its current location in downtown Des Moines. This allowed for the opening of a tap room so beer enthusiasts could visit to sample brews and tour the brewery. The Madhouse tap room opened the summer of 2014.
In 2015, the first Madhouse sour beers were released following prolonged experimentation. Madhouse continues to define itself with a specialization in barrel-aged and sour ales.